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Florfenicol 98%MIN CAS NO.73231-34-2
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- Min.Order: 25 Kilogram
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- Product Details
Keywords
- Florfenicol 98%MIN
- CAS: 73231-34-2 (76639-94-6)
- [R-(R*, R*)]-N-[1-(Fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide; 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
Quick Details
- ProName: Florfenicol 98%MIN
- CasNo: 73231-34-2
- Molecular Formula: C12H14Cl2FNO4S
- Appearance: White crystalline powder
- Application: Antibacterial (veterinary) ;CAS 73231-...
- DeliveryTime: 10days
- PackAge: 25kg/drum
- Port: Shanghai
- ProductionCapacity: 50 Metric Ton/Week
- Purity: 98%
- Storage: Dry and cool condition
- Transportation: By sea
- LimitNum: 25 Kilogram
- Related Substances: 98% Min
- Residue on Ignition: 0.5%
- Heavy Metal: 10ppm
- Valid Period: 2years
Superiority
large production of Florfenicol
Antimex Chemical Limied, was founded in 2001, we are specializing in manufacturing & researching of Active pharmaceutical Ingredients,Veterinary pharm APIs,cosmetic ingredients,and Intermediates. food additives,water treatment chemicals. Fluorine and silicone materials,and some industrial chemical raw materials.Our markets cover all over the world,with the annual turnover of more than 10million dollars.
Our head office located in Shanghai, there are more than 90% of our staff major in chemical or pharmaceutical,we have good relationship with Shanghai University and Zhejiang University. To secure our rapid research transfer capability to meet all kinds of different requiry of clients.Our branch office in Henan, Shandong,and Hongkong, our own three production base are in Shandong, Jiangsu provice. Our Facilities are fully equipped for advanced equipment approved ISO9001:2008, our Pharmaceutical plants production approved by GMP, In quality control,company is provided with most advanced inspection or testing instruments, Hi-tech products can be developed every year to meet the domestic and international market demand.
Process Capability : All product production by GMP plant.
After-sale Service : we can supply technology by customer requirment
Phthalide Chinese Supplier, manufactuer, Phthalide good supplier, Antimex Group, was founded in 2001,we are specializing in manufacturing & researching, warehouse & logistics of Active pharmaceutical Ingredients, pharmaceutical and chemical raw materials, Veterinary pharm APIs, food and feed additives,Chelate agent, Organo Silane,DCDFS(Dichlorodiphenylsilane) and water treatment chemicals Calcium Hipochlorite 65% and 70%. Some intermediate Including DA-6, NAA, IBA, IAA, 6-BA, cppu, compound Sodium Nitrophenolate, 1-MCP，Pharm intermediate and we can supply new products which custom synthesis required, Our markets cover all over the world,with the annual turnover of more than 10million dollars.
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1. Quality
Our products meet safe standard and we have other certificate so yan can get high quality products from our company.
2. Price
We are the company which is the joint of trade and industry so we cao provide the competitive price and high quality product.
3. Packing
We can do according to the customers' request.
4. Transport
The products can be transported by Courier, by air or by sea
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We offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand.
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Details
Florfenicol
Technical Data Sheet
Chemical name:
[R-(R*, R*)]-N-[1-(Fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide; 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide Moleculor Formula : C12H14Cl2FNO4S
Molecular Weight: 358.21
CAS#: 73231-34-2 (76639-94-6)
Molecular Structure:
Specifications:
|
Items |
Specifications |
Results |
| Appearance | White crystalline powder | White crystalline powder |
| Identification | The RT is same with standard sample in HPLC system | Conforms |
| PH | 4.5 ~ 7.0 | 5.10 |
| Melting Point | 153℃ ~ 158℃ | 154.5℃~155.5℃ |
| Optical Rotation | -15° ~ -20° | -17.8° |
| Loss on Drying | ≤ 0.50% | 0.10% |
| Heavy Metal | ≤ 0.002% | Conforms |
| Total Impurities | ≤ 2.0% | 0.70% |
| Max impurity | ≤ 0.50% | 0.24% |
| Assay (Anhydrous) | 98% Min | 99.3% |
| Conclusion | This conforms to enterprise standard | |
Properties: White crystalline powder
Therapeutic Category: Antibacterial (veterinary)
Storage: Store in original container in a cool dark place.
Packing: In 25kg drums with plastic inner.
| Florfenicol Basic information |
| Veterinary antibiotics Pharmacological effects Indications Uses |
| Product Name: | Florfenicol |
| Synonyms: | (r-(r*,s*))-methyleste;2,2-dichloro-n-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl;4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl)-benzenesulfonicaci;FLORFENICOL;AQUAFEN;2,2-dichloro-n-[(1r,2s)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide;NUFLOR;[r-(r*, r*)]-n-[1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide |
| CAS: | 73231-34-2 |
| MF: | C12H14Cl2FNO4S |
| MW: | 358.21 |
| EINECS: | |
| Product Categories: | FEED ADDITIVES;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API;Antimicrobials |
| Mol File: | 73231-34-2.mol |
| Florfenicol Chemical Properties |
| mp | 153 °C |
| storage temp. | 0-6°C |
| form | solid |
| CAS DataBase Reference | 73231-34-2(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
Florfenicol Usage And Synthesis
| Veterinary antibiotics | Florfenicol is currently a commonly used veterinary antibiotic with a broad antibacterial spectrum and a strong antibacterial effect as well as a low the minimum inhibitory concentration (MIC). The antibacterial of florfenicol is about 15-20 times as high as that of chloramphenicol and the thiamphenicol. After administration through feed for 60 minutes, the drug concentration in the tissue can reach peak which can quickly control the disease with having characteristics such as being safe, non-toxic, no residue, and no risk for triggering aplastic anemia. Therefore, it is quite suitable for large-scale farms application. It is mainly used for the treatment of bovine respiratory disease caused by Pasteurella and Haemophilus. It has good efficacy in treating the cattle footrot disease cause by Fusobacterium, and can be also used for treating the infection diseases of pigs and chickens caused by sensitive strains as well as the bacterial disease of fish. It is not easy for bacteria to evolve resistance against florfenicol: Because it has a fluorine atom which replaces the hydroxyl group on the molecular structure of thiamphenicol, thus effectively solving the drug resistant issue of chloramphenicol, and thiamphenicol. Bacteria which are resistant to thiamphenicol, chloramphenicol, amoxicillin, and quinolone remain sensitive to the chemicals. Since chloramphenicol can result in severe adverse reactions such as aplastic anemia and immune suppression, it is banned from being applied in food animal production. Studies have demonstrated that: the major group in the chemical structure of chloramphenicol which causes aplastic anemia is para-nitro in the aromatic ring. Instead, florfenicol has the CH3SO4 which replaces the NO2 groups so that its chemical structure has been changed. In this case, its application to animal will not cause any adverse reactions such as aplastic anemia. Therefore, it is approved for application in more than a dozen of countries such as Japan, Mexico and China. Florfenicol is characterized by: a broad spectrum antibiotic; Salmonella, Escherichia coli, Proteus, Haemophilus, Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae, Streptococcus Suis, swine Pasteurella, Bordetclla bronchiseptica, and Staphylococcus aureus are all sensitive to it. The drug is easy for absorbing and is widely distributed in the body and is quick-acting and long-acting formulations with no potential risk of causing aplastic anemia risks and thus having a better security. In addition, it has an affordable price which is cheaper than other drugs for prevention and treatment of respiratory diseases such as tiamulin, tilmicosin, and azithromycin. The cost of medication is easy for users to accept. Because of all these excellent characteristics, domestic florfenicol is widely applied and has currently become the first-choice drug for prevention and treatment of livestock respiratory diseases and gastrointestinal bacterial infection diseases. Florfenicol is not suitable to be applied in combination with quinolones, penicillins, and cephalosporins, and it has no compatibility with ampicillin, sulfonamides, and furans. The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Pharmacological effects | Florfenicol binds tightly with the 50S subunit of the bacterial ribosome and block the transpeptidation reaction mediated by peptidyl transferase, and thereby suppressing the elongation process of the peptide chain; meanwhile selectively acts on the bacterial 70S ribosome receptors and changes, interferes with the function of peptidyl transferase enzyme. Therefore, it interferes with the bacterial protein synthesis based on dual mechanism. |
| Indications | Florfenicol can strongly interfere with the bacterial protein synthesis. It has a rapid absorption rate and is widely distributed in the body; it has long half-life without side effects such as aplastic anemia; not easy for bacteria to evolve drug resistance, and has no cross-resistance. Florfenicol can be used for the treatment of the systemic infection of livestock and aquatic animals, and has significant efficacy on treating respiratory infections and intestinal infections. Poultry: Escherichia coli disease, salmonellosis, infectious rhinitis, chronic respiratory disease, duck plague and other kinds of mixed infections caused by susceptible strains. Animals: Mixed infections such as infectious pleurisy, asthma, streptococcal disease, Escherichia coli disease, salmonellosis, contagious pleuropneumonia, enzootic pneumonia, paratyphoid piglets yellow white diarrhea, edema disease, atrophic rhinitis, lung epidemic, red white diarrhea piglets, and agalactia syndrome occurred in animals such as pigs, cows, and sheep. Crab: appendages ulcer disease, yellow gills, rotten gill, red legs and red fluorescent body inflammatory disease syndrome. Turtle: red neck disease, furunculosis, shot-hole disease, skin fester disease, inflammatory bowel disease, mumps, and bacterial sepsis. Frogs: cataract syndrome, ascites disease, sepsis, enteritis. Fish: enteritis disease, ascites disease, vibriosis, Edward coli disease. Eel: debonding septicemia (unique effect), Edward coli disease, red skin disease, inflammatory bowel disease. |
| Uses | It is a kind of antibacterial drug. It is used as the veterinary antimicrobial drugs for treating bacterial diseases of pigs, chickens and fish. It has good efficacy in treating the infection disease of pigs, chickens and fish induced by sensitive bacteria, especially for treating respiratory infections and intestinal infections. |
| Chemical Properties | White Crystalline Powder |
| Usage | Fluorinated derivative of thiamphenicol. Inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. An antibacterial |
| Usage | Antibacterial;Protein synthesis inhibitor |
| Usage | Florfenicol is a fluorinated derivative of thiamphenicol. Florfenicol inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. Florfenicol is used as an antibacterial. |
| Usage | Florfenicol is synthesised from thiamphenicol by replacing the 3-hydroxy group with fluorine, first synthesised at Schering in 1980. By replacing the hydroxy group, it was rationalised that chloramphenicol resistance via chloramphenicol acetyltransferase could be eliminated. Florfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Florfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Florfenicol has been extensively studied with over 400 literature citations. |